Martín Fernando Gómez

One copy of the variant. A single functional copy is enough for earwax to be wet, although underarm odor tends to be milder.

The MC1R variants associated with red hair and very fair skin increase the risk of sunburn and melanoma. You do not carry them. This does NOT replace dermatologic check-ups, nor does it change the sun-protection recommendation, which is the same for everyone.

One copy of the variant. It is associated with freckles, lighter hair, and skin that tans less. It is one of the best-replicated pigmentation associations.

One copy of the lightening variant. It is common in populations with mixed ancestry.

One copy of the variant that increases hair diameter. The same variant influences the shape of the incisors and the density of sweat glands.

R160W is another of the MC1R variants associated with red hair, fair skin, and easy sunburn. If the R151C result was also positive, the effects add up.

One copy of the variant. It has been consistently associated with approximately one more cigarette per day and with more difficulty quitting. It does not increase the likelihood of starting to smoke: it acts on the amount, not on the decision.

One copy of the variant associated with the photic sneeze reflex. It is a benign and fairly common trait.

One copy of the variant that slows the breakdown of adenosine, the molecule that builds up sleep pressure. It is associated with more slow-wave sleep —the deep phase— and with greater sensitivity to caffeine, which acts on the same system.

It is the main determinant of eye color and contributes to skin and hair color. A trait with no clinical implication.

Verified against the chip manifest: this variant is an insertion/deletion (1G/2G) and the array does not measure it. It is reported anyway because it usually appears in commercial skin panels. Sun exposure and smoking weigh far more than any genotype, in any case.

One copy of the variant associated with a preference for later hours. Chronotype depends far more on age, the light you get, and your work schedule than on this gene.

APOE is defined by TWO positions (rs429358 and rs7412) and the chip carries only one: without both, the genotype cannot be assigned, so it is not evaluable with this platform. Verified against the manifest. It is worth stating because APOE appears in almost every commercial longevity panel — and because, even if it could be measured, there is today no proven intervention that modifies the associated Alzheimer's risk.

Verified against the manifest: this rsID is not among the positions the chip measures. It is the longevity association that has replicated best —it appears more often in centenarians— but it would require a targeted assay. Even so, the individual effect is small: no one can estimate how long a person will live from a genotype.

Low-grade chronic inflammation is one of the proposed mechanisms of aging. The evidence linking this genotype with life expectancy is preliminary.