Skip to content
A service by Laboratorio Aclimu
Atlas
Genómico
Fictitious patient data · Not a medical result
Genomic report

Martín Fernando Gómez

42 years old · Male

Protocol
DEMO-2026-000123
Sample
14/07/2026
Issued
05/08/2026

You are seeing only the results that can change clinical managementYou are also seeing the results that change no clinical management

Levels C and D are replicated, but there is no evidence that knowing them improves an outcome: that is why the report does not open with them.

Section 5

Polygenic risk

A weighted sum of thousands of small-effect variants, compared against a reference distribution. It indicates a relative position within a population, not an individual probability. The conditions are grouped by body system.

All 14 scores, by what they mean for you

Metabolic
2 conditions2 conditions
Cardiovascular
2 conditions2 conditions
Oncological
2 conditions2 conditions
Autoimmune
5 conditions · 1 in a tail5 conditions · 1 in a tail
Neurological
2 conditions2 conditions
Bone and muscle
1 condition1 condition

Metabolic

2 conditions · all in the average range2 conditions · all in the average range

Diabetes, obesity, and lipids. This is the group where the modifiable outweighs the genetic — and by a wide margin.

Type 2 diabetes

BClear individual signal
78percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Above the average for people of similar genetic ancestry. The weight of the modifiable factors (body weight, physical activity, diet) is still greater than that of the score.

PGS Catalog · PGS0038671,068,166 variants95% CI: percentile 66–87Reference: ~10.5% lifetime risk in the general populationTransferability: moderate

Body mass index

BClear individual signal
66percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

A somewhat above-average predisposition to gain weight easily. It is the clearest example in the whole report that genetics is not in charge: diet and physical activity explain much more of the real variation in weight than this score does.

PGS Catalog · PGS0000272,100,302 variants95% CI: percentile 53–78Reference: Average effect of ~1 kg per score decileTransferability: moderate

Cardiovascular

2 conditions · all in the average range2 conditions · all in the average range

Heart and blood vessels. The scores contribute most in young people who do not yet have the classic risk factors.

Coronary artery disease

BClear individual signal
41percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Within the average. It does not change clinical management: the traditional factors (blood pressure, lipids, smoking) prevail.

PGS Catalog · PGS0000181,745,179 variants95% CI: percentile 29–54Reference: ~8% lifetime risk in the general populationTransferability: moderate

Atrial fibrillation

BClear individual signal
62percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Slightly above the average, with no clinical significance on its own.

PGS Catalog · PGS0000351,168 variants95% CI: percentile 49–74Reference: ~3% lifetime risk in the general populationTransferability: moderate

Oncological

2 conditions · all in the average range2 conditions · all in the average range

No polygenic score evaluates high-penetrance genes (BRCA, Lynch). If there is a family history, a separate hereditary cancer test is warranted.

Prostate cancer

BClear individual signal
55percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Within the average. This score does NOT evaluate BRCA2 or other high-penetrance genes: if there is a family history, a separate hereditary cancer test is warranted.

PGS Catalog · PGS000662269 variants95% CI: percentile 42–68Reference: ~13% lifetime risk in the general populationTransferability: limited

Colorectal cancer

BClear individual signal
34percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Below the average. It does not replace or postpone screening by colonoscopy or occult blood test according to age.

PGS Catalog · PGS0038511,180,765 variants95% CI: percentile 22–48Reference: ~4.5% lifetime risk in the general populationTransferability: moderate

Autoimmune

5 conditions · 1 below percentile 105 conditions · 1 below percentile 10

The group with the greatest real genetic weight, mainly because of the HLA region. Here the scores perform better than in the rest.

Celiac disease

BClear individual signal
8percentile
Somewhat lower risk than average
Percentile 0MedianPercentile 100

Far below the average, consistent with the negative HLA-DQ2/DQ8 result from the nutrigenetics section. When two independent methods agree, the conclusion is firmer: celiac disease is very unlikely.

PGS Catalog · PGS00206758,231 variants95% CI: percentile 3–17Reference: ~1% of the populationTransferability: good

Type 1 diabetes

BClear individual signal
23percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Well below the average. It is one of the best-performing scores in all of common-disease genomics, because a good part of the risk is concentrated in the HLA region, with large, well-characterized effects. It is used clinically to distinguish type 1 diabetes from type 2 and from the monogenic forms (MODY) in doubtful cases.

PGS Catalog · PGS0125551,116,345 variants95% CI: percentile 13–36Reference: ~0.4% of the populationTransferability: moderate

Rheumatoid arthritis

BClear individual signal
47percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Within the average. Autoimmunity scores perform better than the rest because a good part of the weight is in the HLA region, which has large, well-characterized effects.

PGS Catalog · PGS0048186,580,837 variants95% CI: percentile 34–60Reference: ~1% lifetime riskTransferability: moderate

Autoimmune hypothyroidism

BClear individual signal
71percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Slightly above the average. It is a common condition, simple to diagnose with a blood test and with well-established treatment: if symptoms appear, it is investigated and resolved.

PGS Catalog · PGS0047901,841,655 variants95% CI: percentile 58–82Reference: ~5% of women, ~1% of menTransferability: moderate

Inflammatory bowel disease

BClear individual signal
29percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Below the average for Crohn's and ulcerative colitis.

PGS Catalog · PGS0000176,907,112 variants95% CI: percentile 18–43Reference: ~0.5% lifetime riskTransferability: moderate

Neurological

2 conditions · all in the average range2 conditions · all in the average range

It includes conditions with no prevention available today: knowing the number does not enable any management that improves the prognosis, and for some people knowing it weighs on them. They are reported anyway, with that caveat.

Migraine

BClear individual signal
54percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Within the average.

PGS Catalog · PGS0047994,319,950 variants95% CI: percentile 41–67Reference: ~15% of the populationTransferability: moderate

Alzheimer's disease

BClear individual signal
58percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Restricted-access result: there is no proven intervention today that modifies this risk, and knowing it can cause distress without offering an action in return. It is reported only if you explicitly requested it, and reviewing it in consultation rather than reading it alone is recommended.

PGS Catalog · PGS00033422 variants95% CI: percentile 44–71Reference: ~10% after age 65Transferability: limited

Bone and muscle

1 condition · all in the average range1 condition · all in the average range

Bone density and fracture risk, where preventive management is in fact well established.

Osteoporosis

BClear individual signal
62percentile
Risk similar to the population's
Percentile 0MedianPercentile 100

Slightly above the average in risk of low bone density. Here prevention is in fact well established and inexpensive: calcium, vitamin D, weight-bearing activity, and bone densitometry according to age.

PGS Catalog · PGS0048101,876,917 variants95% CI: percentile 49–74Reference: ~20% of postmenopausal womenTransferability: moderate

Not calculated from the panel

The panel carries 16 conditions and 14 were calculated for this sample. The missing ones are listed with the reason: a score that was not calculated is not a low score.

  • Breast cancer — only reported in females
  • Ovarian cancer — only reported in females
These scores depend on imputation

These scores are NOT calculated directly on what the chip measures. Measured against the actual GSA v3 manifest over 60 PGS Catalog scores: the array covers a median of 18% of the variants each score needs —half of the scores fall between 15% and 23%— and none of the 60 reaches the 90% that would be needed to calculate it outright. That is why the imputation step is mandatory, not optional: from the inherited blocks, the missing positions are inferred against a panel of tens of thousands of genomes. A score calculated without imputing would not give an attenuated result, it would give a wrong one — it would end up off-center with respect to the reference distribution it is compared against.

Methodological warning (important)

Percentiles will be normalized by continuous genetic ancestry (projection onto principal components), instead of assigning a fixed population label. That calculation depends on the imputation step, which is not yet resolved: without imputing, none of the scores measured reaches the necessary coverage. Even once resolved: most published scores were derived from cohorts of European ancestry, and their performance in admixed Latin American populations is less validated. To be interpreted as one more layer of information, never as a diagnosis nor as an exact individual probability.

Next: Pharmacogenomics